product name Metolazone
Description: Metolazone is primarily used to treat congestive heart failure and high blood pressure. Metolazone is a thiazide-like diuretic marketed under the brand names Zytanix from Zydus Cadila, Zaroxolyn, and Mykrox. It is primarily used to treat congestive heart failure and high blood pressure. Metolazone indirectly decreases the amount of water reabsorbed into the bloodstream by the kidney, so that blood volume decreases and urine volume increases. This lowers blood pressure and prevents excess fluid accumulation in heart failure. Metolazone is sometimes used together with loop diuretics such as furosemide or bumetanide, but these highly effective combinations can lead to dehydration and electrolyte abnormalities.
References: Am Heart J. 1976 Feb;91(2):262-3; J Kans Med Soc. 1977 Jul;78(7):337-9, 342.
365.83
Formula
C16H16ClN3O3S
CAS No.
17560-51-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 73 mg/mL (199.5 mM)
Water: <1 mg/mL
Ethanol: 8 mg/mL (21.9 mM)
Solubility (In vivo)
Synonyms
SR 720-22
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