product name Alfacalcidol
Description: Alfacalcidol is a non-selective VDR activator medication. Alfacalcidol has been revealed to play a part in bone and mineral homeostasis via binding to the VDR (vitamin D receptor) in calcium-related target organs, such as intestine, bone, kidney and parathyroid gland. In addition, in a high bone-turnover state after OVX, Alfacalcidol has been reported to inhibit osteoclastic bone resorption at pharmacological doses that do not cause hypercalcemia. Apart from these, Alfacalcidol has shown the stimulative effect to the bone formation. Furthermore, Alfacalcidol has been found to enhance bone mass and bone strength at given serum and urinary calcium levels in the OVX model.
References: J Bone Miner Res. 2000 Apr;15(4):770-9.
400.64
Formula
C27H44O2
CAS No.
41294-56-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 80 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: 80 mg/mL (199.7 mM)
Solubility (In vivo)
Synonyms
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