product name Oxymatrine
Description: Oxymatrine (also known as Matrine N-oxide) is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases such as colpitis, psoriasis and eczema etc. Oxymatrine protects mice from fulminant hepatitis induced by GalN/LPS and may block hepatocyte apoptosis and subsequent necrosis through downregulating the production of serum tumor necrosis factor alpha and the expression of Fas and Fas ligand in liver tissue. Oxymatrine also shows anti-hepatitis B virus effect in vivo by reducing the contents of HBsAg and HBcAg in transgenic mice liver.
References: Chin Med J (Engl). 2002 Apr;115(4):593-6; World J Gastroenterol. 2001 Feb;7(1):49-52.
264.36
Formula
C15H24N2O2
CAS No.
16837-52-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 53 mg/mL (200.5 mM)
Water: 53 mg/mL (200.5 mM)
Ethanol: 53 mg/mL (200.5 mM)
Solubility (In vivo)
Synonyms
Matrine N-oxide
other peoduct :
| In Vitro |
In vitro activity: Oxymatrine is a quinolizidine alkaloid extracted from the root of Sophora flavescens, which is used for the treatment of viral hepatitis, cancer, viral myocarditis, gastrointestinal hemorrhage and skin diseases (such as colpitis, psoriasis and eczema). Oxymatrine protects mice from fulminant hepatitis induced by GalN/LPS and may block hepatocyte apoptosis and subsequent necrosis through downregulating the production of serum tumor necrosis factor alpha and the expression of Fas and Fas ligand in liver tissue. Oxymatrine also shows anti-hepatitis B virus effect in vivo by reducing the contents of HBsAg and HBcAg in transgenic mice liver. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | LD50: Mice 521mg/kg (i.p.) |
| Animal model | |
| Formulation & Dosage | |
| References | Chin Med J (Engl). 2002 Apr;115(4):593-6; World J Gastroenterol. 2001 Feb;7(1):49-52. |
