product name Rheic Acid
Description: Rhein (also known as Monorhein; NSC 38629; Rheic acid; Rheinic acid) is an anthraquinone compound enriched in the fresh rhizome of Rheum coreanum Nakai, showing anti-inflammation and antitumor activities. Rhein at 35 μM can effectively inhibit the synthesis of IL-1β on human osteoarthritis synovium, as well as the action of this cytokine at the cartilage level, by reducing the number of chondrocyte IL-1R and inhibiting IL-1β induced NO production in chondrocytes and cartilage. Rhein also induces apoptosis in human promyelocytic leukemia cells (HL-60), characterized by caspase activation, poly(ADP)ribose polymerase (PARP) cleavage, and DNA fragmentation.
References: J Rheumatol. 1998 Apr;25(4):753-62; Arch Biochem Biophys. 2003 Oct 15;418(2):99-107; Planta Med. 2010 Jan;76(1):27-33.
284.22
Formula
C15H8O6
CAS No.
478-43-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: <1 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Rhein, Monorhein, NSC 38629, Rheinic Acid
other peoduct :
| In Vitro |
In vitro activity: Rhein at 35 μM can effectively inhibit the synthesis of IL-1β on human osteoarthritis synovium, as well as the action of this cytokine at the cartilage level, by reducing the number of chondrocyte IL-1R and inhibiting IL-1β induced NO production in chondrocytes and cartilage. Rhein also induces apoptosis in human promyelocytic leukemia cells (HL-60), characterized by caspase activation, poly(ADP)ribose polymerase (PARP) cleavage, and DNA fragmentation. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Rhein is also effective in ameliorating diabetic renal pathological changes and attenuating hyperlipidemia in db/db mice with diabetic nephropathy with decreased transforming growth factor-beta1 (TGF-beta1) and fibronectin immunohistochemistry expression in renal tissue and reduced cholesterol (Chol), triglyceride (TG), low-density lipoprotein cholesterol (LDL-C) and ApoE in plasma. |
| Animal model | |
| Formulation & Dosage | |
| References | J Rheumatol. 1998 Apr;25(4):753-62; Arch Biochem Biophys. 2003 Oct 15;418(2):99-107; Planta Med. 2010 Jan;76(1):27-33. |
