product name Sophocarpine
Description: Sophocarpine, a major ingredient of Sophora alopecuroides, has a wide range of pharmacological effects. Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM.
References: Int Immunopharmacol. 2008 Dec 20;8(13-14):1767-72; Phytother Res. 2002 Mar;16(2):154-6; Biol Pharm Bull. 2008 Apr;31(4):627-32.
246.35
Formula
C15H22N2O
CAS No.
145572-44-7
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 49 mg/mL (198.9 mM)
Water: 49 mg/mL (198.9 mM)
Ethanol: 49 mg/mL (198.9 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Sophocarpine exerts anti-cachectic effects by inhibiting TNF-α and IL-6 production in both RAW264.7 cells and murine primary macrophages. Sophocarpine also shows antivirus activity by inhibiting HHV-6 replication in Molt-3 cells. In addition, Sophocarpine is a potent blocker of HERG K+ channels with an IC50 of about 200 mM. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Administration of 50 mg/kg/d sophocarpine for 5 days from the onset of cachexia does not inhibit the tumor growth but results in attenuation of cachexia symptoms in colon26 adenocarcinoma xenograft BALB/c mice. LD50: Mice 63.94mg/kg (i.v.). |
| Animal model | |
| Formulation & Dosage | |
| References | Int Immunopharmacol. 2008 Dec 20;8(13-14):1767-72; Phytother Res. 2002 Mar;16(2):154-6; Biol Pharm Bull. 2008 Apr;31(4):627-32. |
Pasireotide (ditrifluoroacetate)
