product name Bergenin
Description: Bergenin is an isocoumarin isolated from various medicinal plants. It shows mild anti-HIV activity,antihepatotoxic activity and antiulcer activity. It is trihydroxybenzoic acid glycoside and is the C-glycoside of 4-O-methyl gallic acid. It possesses an O-demethylated derivative called norbergenin. These are chemical compounds and drugs of Ayurveda, commonly known as Paashaanbhed. It shows a potent immunomodulatory effect.
References: Inflammation. 2015;38(3):1142-50; Arch Pharm Res. 2015 Jun;38(6):1248-54.
328.27
Formula
C14H16O9
CAS No.
477-90-7
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: > 10 mM
Water:
Ethanol:
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis. |
| Animal model | |
| Formulation & Dosage | |
| References | Inflammation. 2015;38(3):1142-50; Arch Pharm Res. 2015 Jun;38(6):1248-54. |
