product name Apramycin Sulfate
Description: Apramycin (also known as Ai3-29795) is an aminoglycoside antibiotic, which binds to the deep groove of the RNA. Apramycin consumption at farm level is most probably driving the increasing occurrence of apramycin/gentamicin cross-resistant [aac(3)-IV positive] E. coli in diseased pigs and healthy finishers at slaughter. Apramycin inhibits A. pleuropneumoniae FMV 87-682 with MIC50 of 8 mg/L. Apramycin (1/4 MIC) in the medium decreases the rate of growth of the bacterial strains tested, and causes the postantibiotic effect (PAE) up to 5 hours.
References: J Antimicrob Chemother. 2006 Jul;58(1):101-7; Int J Antimicrob Agents. 1999 Aug;12(3):229-37; Immunopharmacol Immunotoxicol. 1992;14(1-2):191-205.
637.66
Formula
C21H41N5O11.xH2O4S
CAS No.
65710-07-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: <1 mg/mL
Water: 100 mg/mL (156.82 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Ai3-29795
other peoduct :
| In Vitro |
In vitro activity: Apramycin consumption at farm level is most probably driving the increasing occurrence of apramycin/gentamicin cross-resistant [aac(3)-IV positive] E. coli in diseased pigs and healthy finishers at slaughter. Apramycin inhibits A. pleuropneumoniae FMV 87-682 with MIC50 of 8 mg/L. Apramycin (1/4 MIC) in the medium decreases the rate of growth of the bacterial strains tested, and causes the postantibiotic effect (PAE) up to 5 hours. Apramycin significantly reduces the haemolytic activity of A. pleuropneumoniae and affects the capsular material production of this isolate and of one isolate of P. multocida (type A). Apramycin induces translation errors, as assayed by incorporation of leucine, isoleucine and serine, although this effect occurs only to a limited extent, in cell-free systems from Escherichia coli programmed with poly(U). Apramycin inhibits the translocation step of protein synthesis both in vivo, in protoplasts of Bacillus megaterium, and in vitro, in cell-free systems from E. coli. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Apramycin (225 mg/L) totally suppresses mortality and significantly reduces Salmonella excretion in comparison with non-treated chicks. |
| Animal model | |
| Formulation & Dosage | |
| References | J Antimicrob Chemother. 2006 Jul;58(1):101-7; Int J Antimicrob Agents. 1999 Aug;12(3):229-37; Immunopharmacol Immunotoxicol. 1992;14(1-2):191-205. |
