product name Luliconazole
Description: Luliconazole (also known as NND 502) is an azole antifungal agent that is used for the topical treatment of interdigital tinea pedis. Luliconazole is a broad-spectrum antifungal drug that inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 µg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 µg/ml). Luliconazole demonstrates greater potency against Trichophyton spp.
References: J Infect Chemother. 2004 Aug;10(4):216-9; Med Mycol. 2009;47(6):640-7; Med Mycol. 2010 May;48(3):491-7.
354.28
Formula
C14H9Cl2N3S2
CAS No.
187164-19-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 71 mg/mL (200.4 mM)
Water: <1 mg/mL
Ethanol: 5 mg/mL (14.1 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Luliconazole inhibits growth of all filamentous fungi except zygomycetes at low concentrations (MIC, ≦0.004–0.125 µg/ml), with dermatophytes being most susceptible (MIC, ≦0.004–0.008 µg/ml). Luliconazole demonstrates greater potency against Trichophyton spp. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Luliconazole (1% cream) treatment produces a clinical effi cacy somewhat below terbinafine with 50.8% in a guinea pig model of dermatophytosis. Luliconazole (1% cream) treated guinea pigs have hairs covered with amorphous debris and a small number of conidia are detected. The improved efficacy of Luliconazole over Lanoconazole is likely due to Luliconazole being strictly an R-enantiomer while lanoconazole is a racemic mixture. |
| Animal model | |
| Formulation & Dosage | |
| References | J Infect Chemother. 2004 Aug;10(4):216-9; Med Mycol. 2009;47(6):640-7; Med Mycol. 2010 May;48(3):491-7. |
