product name CORM-3
Description: CORM-3 is a water-soluble carbon monoxide-releasing molecule with anti-inflammatory and cardioprotective activity. As a CO-releasing molecule, CORM-3 can mimic the anti-allergic and anti-anaphylactic effects of heme oxygenase through the activation of the soluble guanylyl cyclase. CORM-3 is reported to have effects on cardiovascular inflammation. It reduces PMN-induced CD54 expression on EC in an in vitro model. CORM-3 also has vasoactive properties in vitro and in vivo. It shows significant vasodilatation through acting as a regulator of vessel tone and blood pressure.
References: Circ Res. 2003 Jul 25;93(2):e2-8; Br J Pharmacol. 2005 Jul;145(6):800-10; Ann Rheum Dis. 2008 Sep;67(9):1211-7.
294.61
Formula
C5H4ClNO5Ru
CAS No.
475473-26-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 38 mg/mL (129 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: CORM-3 protects against hypoxia-reoxygenation and oxidative stress by promoting CO release in cardiac cells. CORM-3 attenuates the inflammatory response induced by LPS in RAW264.7 murine macrophages. CORM-3 also uncouples mitochondrial respiration via interaction with the phosphate carrier. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | CORM-3 (40 mg/kg i.p.) prolongs the survival of murine cardiac grafts and attenuates organ rejection in CBA mice transplanted with BALB/c hearts. CORM-3 (20 mg/kg i.p.) decreases cellular infiltration, joint inflammation and destruction in a collagen-induced arthritis mouse model. |
| Animal model | CBA mice transplanted with BALB/c hearts. |
| Formulation & Dosage | Dissolved in saline; 40 mg/kg daily; i.p. injection |
| References | Circ Res. 2003 Jul 25;93(2):e2-8; Br J Pharmacol. 2005 Jul;145(6):800-10; Ann Rheum Dis. 2008 Sep;67(9):1211-7. |
