product name Dicumarol
Description: Dicoumarol (also named Dicumarol) is a competitive NADH quinone oxidoreductase (NQO1) inhibitor, it is used as an anticoagulant by interfering with the metabolism of vitamin K. Dicoumarol is a naturally occurring anticoagulant that functions as a functional vitamin K depleter, similar to warfarin, a drug that dicoumarol inspired. It is also used in biochemical experiments as an inhibitor of reductases. Like all 4-hydroxycoumarin drugs it is a competitive inhibitor of vitamin K epoxide reductase, an enzyme that recycles vitamin K, thus causing depletion of active vitamin K in blood.
References: J Biol Chem. 2006 Dec 8;281(49):37416-26; Clin Cancer Res. 2004 Jul 1;10(13):4550-8.
336.29
Formula
C19H12O6
CAS No.
66-76-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 67 mg/mL (199.2 mM)
Water: <1 mg/mL
Ethanol: 67 mg/mL (199.2 mM)
Solubility (In vivo)
Synonyms
Dicumarol
other peoduct :
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
