product name Oleuropein
Description: Oleuropein is an antioxidant polyphenol isolated from olive leaf. In both J774A.1 cells and primary mouse macrophages, Oleuropein increases LPS-induced NO production. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. In TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells, Oleuropein inhibits cell proliferation and migration. In swiss albino mice that spontaneously develop soft tissue sarcomas, Oleuropein (i.p. or p.o.) completely regresses tumors. In rats, Oleuropein (40 mg/kg, p.o.) protects from cardiac remodeling process after isoproterenol-induced myocardial infarction through inhibiting angiotensin-converting enzyme activity.
References: Life Sci. 1998;62(6):541-6; Biochem Biophys Res Commun. 2005 Sep 2;334(3):769-78.
540.51
Formula
C25H32O13
CAS No.
32619-42-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (185.0 mM)
Water: 100 mg/mL (185.0 mM)
Ethanol: 100 mg/mL (185.0 mM)
Solubility (In vivo)
PBS: 30mg/mL
Synonyms
other peoduct :
| In Vitro |
In vitro activity: In both J774A.1 cells and primary mouse macrophages, Oleuropein increases LPS-induced NO production. Oleuropein prevents oxidative myocardial injury induced by ischemia and reperfusion. In TF-1a; 786-O, T-47D, RPMI-7951, LoVo, and NL-Fib cells, Oleuropein inhibits cell proliferation and migration. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | In swiss albino mice that spontaneously develop soft tissue sarcomas, Oleuropein (i.p. or p.o.) completely regresses tumors. In rats, Oleuropein (40 mg/kg, p.o.) protects from cardiac remodeling process after isoproterenol-induced myocardial infarction through inhibiting angiotensin-converting enzyme activity. |
| Animal model | Swiss albino mice that spontaneously develops soft tissue sarcomas |
| Formulation & Dosage | Dissolved in PBS; 50 μg/mouse; i.p. or p.o. administration |
| References | Life Sci. 1998;62(6):541-6; Biochem Biophys Res Commun. 2005 Sep 2;334(3):769-78. |
