product name DDR1-IN-1
Description: DDR1-IN-1 is a potent and selective discoidin domain receptor 1 (DDR1) receptor tyrosine kinase inhibitor with IC50 of 105 nM, and is about 3-fold selectivity over DDR2. DDR1-IN-1 binds to DDR1 in the DFG-out conformation and inhibits DDR1 autophosphorylation in cells at submicromolar concentrations with good selectivity as assessed against a panel of 451 kinases measured. DDR1-IN-1 provides a useful pharmacological probe for DDR1-dependent signal transduction. The DDR1 receptor tyrosine kinase is activated by matrix collagens and has been implicated in numerous cellular functions such as proliferation, differentiation, adhesion, migration, and invasion.
References: ACS Chem Biol. 2013 Oct 18;8(10):2145-50.
552.59
Formula
C30H31F3N4O3
CAS No.
1449685-96-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (181 mM)
Water: <1 mg/mL
Ethanol: 4 mg/mL (7.2 mM)
Solubility (In vivo)
Synonyms
other peoduct :
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