product name Albendazole
Description: Albendazole (also alled SKF-62979) is a member of the benzimidazole compounds used as a drug indicated for the treatment of a variety of worm infestations. Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle.
References: Toxicol Appl Pharmacol. 1991 Jun 1;109(1):73-84; J Pharmacol Exp Ther. 2005 Dec;315(3):1036-45.
265.33
Formula
C12H15N3O2S
CAS No.
54965-21-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 17 mg/mL (64.1 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
SKF-62979
other peoduct :
| In Vitro |
In vitro activity: Albendazole is reported to be teratogenic in rats, and is extensively metabolized to the sulfoxide derivative. Albendazole and its sulfoxide metabolite elicit an accumulation of cells in the mitotic phase of the cell cycle. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Albendazole causes an induction of hepatic activities of CYP1A1-associated ethoxyresorufin O-deethylase (EROD) 65 fold, CYP1A2-associated methoxyresorufin O-demethylase (MROD) 6 fold, CYP2B1-associated penthoxyresorufin O-dealkylase (PROD) 4 fold, CYP2B2-associated benzyloxyresorufin O-dealkylase (BROD) 14 fold, as well as a partial reduction of CYP2E1-associated 4-nitrophenol hydroxylase (4-NPH) activity in the rat. Albendazole is metabolized to its pharmacologically active sulfoxide metabolites by liver and lung microsomes from sheep and cattle, as well as by cattle intestinal microsomes. Albendazole (ABZ) is a benzimidazole derivative with a broad spectrum of activity against human and animal helminthe parasites. Albendazole and its metabolites are extensively distributed to the digestive tract, mainly into the abomasal fluid, after the i.v. and i.r. administrations. Albendazole and its active albendazole sulphoxide (ABZSO) metabolite are recovered in tapeworms collected from both i.v. and i.r. treated lambs. |
| Animal model | |
| Formulation & Dosage | |
| References | Toxicol Appl Pharmacol. 1991 Jun 1;109(1):73-84; J Pharmacol Exp Ther. 2005 Dec;315(3):1036-45. |
