product name YH239-EE
References: ACS Chem Biol. 2014 Mar 21;9(3):802-11.
504.41
Formula
C25H27Cl2N3O4
CAS No.
1364488-67-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (198.3 mM)
Water: <1 mg/mL (slightly soluble or insoluble)
Ethanol: 18 mg/mL (35.7 mM)
Solubility (In vivo)
Chemical Name
Ethyl 3-(2-(tert-butylamino)-1-(N-(4-chlorobenzyl)formamido)-2-oxoethyl)-6-chloro-1H-indole-2-carboxylate
other peoduct :
| YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion). | |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | [1] Huang Y, et al. ACS Chem Biol. 2014, 9(3), 802-811. |
