product name WS3
Description: WS 3 is an agonist of TRPM8 receptor with EC50 value of 3.7 μM. WS 3 is an agonist of TRPM8 receptor and a cooling agent. In HEK cells stably expressing either hTRPM8 or hTRPA1, WS 3 activated hTRPM8 and hTRPA1 with EC50 values of 2.2 and 120.6 μM, respectively. WS 3 was efficacious in eliciting cooling sensation.
References: Chem Senses. 2011 Sep;36(7):649-58.; J Am Chem Soc. 2013 Feb 6;135(5):1669-72; ACS Chem Biol. 2013 Jul 19;8(7):1407-11.
569.58
Formula
C28H30F3N7O3
CAS No.
1421227-52-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (175.6 mM)
Water: <1 mg/mL
Ethanol: 80 mg/mL warmed (140.5 mM)
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: WS3 induces proliferation of the mouse β cell line R7T1 with EC50 of 0.074 μM. WS3 reversibly induces proliferation of primary fetal and adult human retinal pigment epithelial (RPE) cells. Kinase Assay: Cell Assay: R7T1 cells are growth-arrested by removal of doxycycline for 2 days and plated into 384-well plates at a density of 3,000 cells/well in growth medium. Β cell proliferation is assessed using CellTiter Glo after 4 days. Fold increase in cell number is calculated by normalizing compound-treated wells to the median of DMSO-treated wells. |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Chem Senses. 2011 Sep;36(7):649-58.; J Am Chem Soc. 2013 Feb 6;135(5):1669-72; ACS Chem Biol. 2013 Jul 19;8(7):1407-11. |
