product name Limonin
Description: Limonin (also known as limonoate D-ring-lactone and limonoic acid di-delta-lactone) is a triterpenoid enriched in citrus fruits and other plants, which has antivirus and antitumor ability. It is a bitter, white, crystalline substance. Chemically, it is a member of the class of compounds known as furanolactones. Citrus seed extracts reportedly have antiviral properties, inhibiting replication of retroviruses like HIV-1 and HTLV-I. Neuroprotective effects of limonin have also been described.
References: Planta Med. 2003 Oct;69(10):910-3; Planta Med. 1998 May;64(4):339-42.
470.51
Formula
C26H30O8
CAS No.
1180-71-8
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 44 mg/mL (93.5 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :
| In Vitro |
In vitro activity: Limonin is a furanolactone enriched in citrus fruits, which has antivirus and antitumor ability. Limonin inhibits the replication of human immunodeficiency virus-1 (HIV-1) in culture of human peripheral blood mononuclear cells (PBMC) with an EC50 of 60 μM. Limonin also shows antinociceptive and anti-inflammatory effects in vivo. Limonin is a potent anti proliferative agent against human hepatoma HepG2 cells via regulation of apoptosis and Wnt signallings. Kinase Assay: Cell Assay: When culturing the HIV-1 in human peripheral blood mononuclear cells (PBMC) and monocytes/macrophages (M/M), Limonin inhibit the HIV-1 replication in all cellular systems and inhibit HIV-1 replication with EC50 value of 60u μM in PBMC cells in a dose-dependent way. In human hepatoma HepG2 cells, limonin can induced apoptosis, which was evidenced by WB analysis of some apoptosis factors. |
|---|---|
| In Vivo | In the female Syrian hamsters treated with DMBA, which can cause tumor, limonin showed a 60% reduction in tumor burden. It decreased 20% tumor number and 50% tumor mass. In male F344 rats treated with azoxymethane (AOM), 0.05% limonin in diet significantly reduced (65%-92% inhibition) the incidence of colonic adenocarcinoma. Thus, limonin has chemopreventive effects on chemically induced carcinogenesis. |
| Animal model | |
| Formulation & Dosage | |
| References | Carcinogenesis. 1989 Aug;10(8):1535-7; Biofactors. 2000;13(1-4):213-8. |
