product name Lidocaine
Description: Lidocaine (also known as Alphacaine) is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Lidocaine is a local anesthetic and cardiac depressant used as an antiarrhythmia agent. Originally developed as a local anesthetic, it has properties as a class IB antiarrhythmic, a long-acting membrane stabilizing agent used against ventricular arrhythmia. Its actions are more intense and its effects more prolonged than those of procaine but its duration of action is shorter than that of bupivacine or prilocaine.
References: Acta Anaesthesiol Scand. 2015 Jan;59(1):47-55.
234.34
Formula
C14H22N2O
CAS No.
137-58-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 47 mg/mL (200.6 mM)
Water: 9 mg/mL (38.4 mM)
Ethanol: 47 mg/mL (200.6 mM)
Solubility (In vivo)
Synonyms
Alphacaine
| In Vitro |
In vitro activity: Lidocaine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Acta Anaesthesiol Scand. 2015 Jan;59(1):47-55. |
