product name BIO-acetoxime
Description: BIO-acetoxime is a potent and selective dual GSK3α/β inhibitor with IC50 of 10 nM, it showed >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B. BIO-Acetoxime reduces invasiveness of gliomas and extends animal survival in intracranial glioma models. Also, BIO-Acetoxime induces Wnt signaling and inhibits CD8+ T cell effector differentiation. BIO-acetoxime is a synthetic derivative of a compound from the Mediterranean mollusk Hexaplex trunculus.
References: J Med Chem. 2004;47(4):935-46; Mol Cell Biol. 2015;35(17):3029-43; Mol Cancer Ther. 2014;13(2):454-67.
398.21
Formula
CC18H12BrN3O3
CAS No.
667463-85-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 19 mg/mL (47.7 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
GSK-3 Inhibitor X;6-Bromoindirubin-3′-acetoxime
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19424091
| In Vitro |
In vitro activity: In human oral epithelial cells, BIO-acetoxime suppresses viral gene expression and protects oral epithelial cells from HSV-1 infection. In SY5Y-MYCN cells, BIO-acetoxime strongly reduces c-MYC expression and p-SMAD3 levels. BIO-acetoxime also decreases cell viability of KCN, KCNR, SY5Y, Kelly, and IMR32 cells by mediating apoptosis.] In HEK 293T cells, BIO-acetoxime is also found to reduce antiviral innate immunity downstream of IRF3 activation by inhibition of GSK3α/β activities. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | J Med Chem. 2004 Feb 12;47(4):935-46; Mol Cell Biol. 2015 Sep 1;35(17):3029-43; Mol Cancer Ther. 2014 Feb;13(2):454-67. |
