product name Dihydromyricetin
Description: Dihydromyricetin (also known as Ampelopsin, Ampeloptin) is a natural antioxidant flavonoid from Ampelopsis grossedentata. It can be found in Cedrus deodara or in the Japanese raisin tree (Hovenia dulcis). It is also found in Erythrophleum africanum. The compound is credited with hepatoprotective effects observed in rodents. Use of Hovenia species in traditional Chinese herbal medicine as a hangover cure has led to research into the potential action of dihydromyricetin in counteracting the effects of alcohol in the brain.
References: Yao Xue Xue Bao. 2003 Apr;38(4):241-4; J Neurosci. 2012 Jan 4;32(1):390-401.
320.25
Formula
C15H12O8
CAS No.
27200-12-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 64 mg/mL (199.8 mM)
Water: 5 mg/mL (20.3 mM)
Ethanol: 64 mg/mL (199.8 mM)
Solubility (In vivo)
Synonyms
Ampeloptin
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19422052
| In Vitro |
In vitro activity: Dihydromyricetin shows antioxidant activity as an effective scavenger of 1,1-diphenyl-2-picrylhydrazyl radical (DPPH). It also inhibits the increase of lipid peroxidation (LPO) values in linolei acid system catalyzed by FeSO4-edetic acid. DHM (1 μM) as a novel anti-alcohol intoxication medication antagonizes both acute EtOH-induced potentiation of GABA(A)Rs and EtOH exposure/withdrawal-induced GABA(A)R plasticity and increases in GABA(A)R alpha4 subunit expression in hippocampus and cultured neurons. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Dihydromyricetin (1 mg/kg, i.p.) counteracts acute alcohol (EtOH) intoxication, and also withdrawals signs in rats including tolerance, increased anxiety, and seizure susceptibity. LD50: Mice 1.41g/kg (i.p.) |
| Animal model | |
| Formulation & Dosage | |
| References | Yao Xue Xue Bao. 2003 Apr;38(4):241-4; J Neurosci. 2012 Jan 4;32(1):390-401. |
