product name PF-431396
Description: PF-431396 is a novel, potent dual PYK2/FAK inhibitor with IC50 of 11 nM and 2 nM, respectively. PF-431396 promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. PF-431396 is used in treatment of osteoporosis.
References: J Biol Chem. 2009 May 8;284(19):13193-201; J Biol Chem. 2009 Aug 21;284(34):22865-77.
506.5
Formula
C22H21F3N6O3S
CAS No.
717906-29-1
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 100 mg/mL (197.43 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19420181
| In Vitro |
In vitro activity: In A20 cells, PF-431396 blocks anti-Ig- and clustering LFA-1-induced tyrosine phosphorylation of Pyk2 and FAK, and further blocks B cell spreading. PF-431396 consistently inhibits the increase in protein tyrosine phosphorylation (PY) induced by the absence of added calcium and induced by W-7 in the presence of calcium. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | J Biol Chem. 2009 May 8;284(19):13193-201; J Biol Chem. 2009 Aug 21;284(34):22865-77. |
