product name Drospirenone
Description: Drospirenone, also known as 1,2-dihydrospirorenone, or ZK 3059 is a steroidal progestin of the spirolactone group used in birth control pills and postmenopausal hormone replacement therapy pills. Drospirenone is an ingredient in some birth control pills and hormone replacement therapy. In combination with ethinylestradiol it is used as contraception.
References: Contraception. 1996 Oct;54(4):243-51; Contraception. 1995 Feb;51(2):99-110; Climacteric. 2004 Mar;7(1):103-11.
366.49
Formula
C24H30O3
CAS No.
67392-87-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 73 mg/mL (199.2 mM)
Water: <1 mg/mL
Ethanol: 11 mg/mL (30.0 mM)
Solubility (In vivo)
Synonyms
ZK 3059
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19419300
| In Vitro |
In vitro activity: Drospirenone is a novel progestin under clinical development that is similar to the natural hormone progesterone, combining potent progestogenic with antimineralocorticoid and antiandrogenic activities. drospirenone was devoid of glucocorticoid activity. Both progestins did not show any antiglucocorticoid action. Furthermore, drospirenone and progesterone both showed considerable antimineralocorticoid activity and weak mineralocorticoid activity. the pharmacological profile of drospirenone is more closely related to that of the natural hormone progesterone than is that of any other synthetic progestogen in use today. Therefore, drospirenone is anticipated to give rise to a number of additional health benefits both for users of oral contraceptives and hormone replacement therapy recipients. The combination of 17beta-estradiol and drospirenone has a positive effect on BMD and a potentially beneficial effect on lipids. Although endometrial thickness increased slightly, the safety of the endometrium was assured, as no cases of hyperplasia or cancer occurred. Kinase Assay: Cell Assay: |
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| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Contraception. 1996 Oct;54(4):243-51; Contraception. 1995 Feb;51(2):99-110; Climacteric. 2004 Mar;7(1):103-11. |
