product name Hexestrol
Description: Hexestrol (also known as Bibenzyl) binds to ERα and ERβ with EC50 of 0.07 nM and 0.175 nM, respectively. inhibits activity of AKR1B13 with IC50 of 3.2 μM. Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM.
References: Eur J Med Chem. 2009 Sep;44(9):3412-24; Ann N Y Acad Sci. 2004 Dec;1028:247-57.
270.37
Formula
C18H22O2
CAS No.
84-16-2
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 42 mg/mL (155.3 mM)
Water: <1 mg/mL
Ethanol: 42 mg/mL (155.3 mM)
Solubility (In vivo)
30% Propylene glycol, 5% Tween 80, 65% D5W: 30 mg/mL
Synonyms
Bibenzyl
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19417594
| In Vitro |
In vitro activity: Hexestrol binds to ERα with EC50 of 0.07 nM and to ERβ with EC50 of 0.175 nM. Hexestrol inhibits activity of AKR1B13 with IC50 of 3.2 μM. Hexestrol inhibits the d-galactose dehydrogenase activity of thermophilus aldose 1-dehydrogenase with IC50 of 0.063 mM. Hexestrol inhibits the dehydrogenase activity of AKR1C20 towards 10 μM 4-androsten-3α-o1-17-one with IC50 values of 2.7 μM. Hexestrol inhibits 17HSD5 with IC50 of 30 μM, and inhibits TBER1 with IC50 of 0.8 μM. Hexestrol reacts with DNA through the catechol quinone, thus can be a carcinogen. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Hexestrol administered intraperitoneally at dose of 6 mg/kg may decrease ovulation in mice, as evident by smaller ovaries and decreased luteal bodies and oocytes. |
| Animal model | Mice |
| Formulation & Dosage | Dissolved in saline; 3 mg/kg and 6 mg/kg; i.p. injection |
| References | Eur J Med Chem. 2009 Sep;44(9):3412-24; Ann N Y Acad Sci. 2004 Dec;1028:247-57. |
