product name SKF38393 HCl
Description: SKF38393 HCl is a selective dopamine D1 receptor agonist with an IC50 value of 110 nM, the (+)-enantiomer is the active isomer. In locally anesthetized, artificially respired, gallamine-treated rats, i.v. administration of SKF 38393 significantly altered dopamine cell activity. In these rats, firing rate increases and decreases were also observed.
References: Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2446-50; Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7.
291.77
Formula
C16H17NO2 . HCl
CAS No.
62717-42-4
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 58 mg/mL (198.8 mM)
Water: <1 mg/mL
Ethanol: 6 mg/mL (20.6 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19413959
| In Vitro |
In vitro activity: SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. |
| Animal model | Male Wistar rats |
| Formulation & Dosage | Dissolved in saline; 6 mg/kg; i.p. injection |
| References | Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2446-50; Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7. |
