product name Cyclocytidine HCl
Description: Cyclocytidine (also known as Ancitabine, and NSC 145668 HCl) is the prodrug of cytarabine, which is a pyrimidine nucleoside analog that inhibits the DNA synthesis and used mainly in the treatment of leukemia. Cyclocytidine is structurally similar to human deoxycytidine and can be incorporated into human DNA and then kills the cell. Cyclocytidine most affects rapidly dividing cells, which require DNA replication for mitosis. Cyclocytidine also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis.
References: J Pharm Sci. 1984 Jul;73(7):896-902; Biochem Pharmacol. 1972 Feb 15;21(4):465-75.
261.66
Formula
C9H12ClN3O4
CAS No.
10212-25-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 52 mg/mL (198.7 mM)
Water: 44 mg/mL (168.2 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
NSC 145668 HCl
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19412155/
| In Vitro |
In vitro activity: Cyclocytidine HCl (Ancitabine) is the prodrug of cytarabine, which is structurally similar to human deoxycytidine to be incorporated into human DNA and then kills the cell. Cyclocytidine most affects rapidly dividing cells, which require DNA replication for mitosis. Cyclocytidine also inhibits both DNA and RNA polymerases and nucleotide reductase enzymes needed for DNA synthesis. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Cyclocytidine is a potent immunosuppresant, antiviral and antitumor agent in animals and man, maximum inhibitor effects require the use of complex injection schedules. Cyclocytidine provides treatment for leukemia. |
| Animal model | BDF1 mice inoculated L1210 cells |
| Formulation & Dosage | Dissolved in Vehicle 122; 20 or 100 mg/kg/day; i.p. or s.c. administration |
| References | J Pharm Sci. 1984 Jul;73(7):896-902; Biochem Pharmacol. 1972 Feb 15;21(4):465-75. |
