product name Tetrandrine
Description: Tetrandrine (also called Fanchinine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a potent calcium channel blocker. Tetrandrine blocks the L-type (IC50= 0.3-8 µM) and T-type (IC50= 2.5-20 µM) calcium channels. It is also a potent blocker of the Ca2+-activated K+ channel (Kd= 0.2 µM). Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM.
References: Pflugers Arch. 1992 Sep;421(6):558-65; Acta Pharmacol Sin. 2004 Mar;25(3):327-33.
622.75
Formula
C38H42N2O6
CAS No.
518-34-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: <1 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Fanchinine
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19403827
| In Vitro |
In vitro activity: Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Pflugers Arch. 1992 Sep;421(6):558-65; Acta Pharmacol Sin. 2004 Mar;25(3):327-33. |
Related Posts
product name Tetrandrine
Description: Tetrandrine (also called Fanchinine), a bis-benzylisoquinoline alkaloid derived from Stephania tetrandra, is a potent calcium channel blocker. Tetrandrine blocks the L-type (IC50= 0.3-8 µM) and T-type (IC50= 2.5-20 µM) calcium channels. It is also a potent blocker of the Ca2+-activated K+ channel (Kd= 0.2 µM). Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM.
References: Pflugers Arch. 1992 Sep;421(6):558-65; Acta Pharmacol Sin. 2004 Mar;25(3):327-33.
622.75
Formula
C38H42N2O6
CAS No.
518-34-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: <1 mg/mL
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Fanchinine
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19403827
| In Vitro |
In vitro activity: Tetrandrine inhibits voltage-gated Ca2+ currents with an IC50 of 10.1 mM in isolated nerve terminals of the rat neurohypophysis. Tetrandrine is a high-affinity blocker of the type II, maxi-Ca(2+)-activated K+ channel of the rat neurohypophysial terminals with an IC50 of 0.21 mM. Another study shows that Tetrandrine also inhibits Ca(2+)-activated Cl- currents (I(Cl,Ca)) with an IC50 of 5.2 mM. Tetrandrine inhibits the proliferation of human leukemic HL-60 cells via induction of apoptosis. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Pflugers Arch. 1992 Sep;421(6):558-65; Acta Pharmacol Sin. 2004 Mar;25(3):327-33. |