product name Flunarizine 2HCl
Description: Flunarizine 2HCl is a dihydrochloride salt form which is a selective calcium channel blocker with a Ki of 68 NM. Flunarizine has been shown to inhibit contraction of isolated murine caudal artery preparations. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia.
References: Biochem Pharmacol. 1983 Mar 1;32(5):765-71; Res Commun Chem Pathol Pharmacol. 1988 Nov;62(2):147-60.
477.42
Formula
C26H26F2N2.2HCl
CAS No.
30484-77-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 5 mg/mL (10.5 mM)
Water: <1 mg/mL
Ethanol: 3 mg/mL (6.3 mM)
Solubility (In vivo)
Synonyms
KW-3149, R14950
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19403654
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
Related Posts
product name Flunarizine 2HCl
Description: Flunarizine 2HCl is a dihydrochloride salt form which is a selective calcium channel blocker with a Ki of 68 NM. Flunarizine has been shown to inhibit contraction of isolated murine caudal artery preparations. It is effective in the prophylaxis of migraine, occlusive peripheral vascular disease, vertigo of central and peripheral origin, and as an adjuvant in the therapy of epilepsy. It may help to reduce the severity and duration of attacks of paralysis associated with the more serious form of alternating hemiplegia.
References: Biochem Pharmacol. 1983 Mar 1;32(5):765-71; Res Commun Chem Pathol Pharmacol. 1988 Nov;62(2):147-60.
477.42
Formula
C26H26F2N2.2HCl
CAS No.
30484-77-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 5 mg/mL (10.5 mM)
Water: <1 mg/mL
Ethanol: 3 mg/mL (6.3 mM)
Solubility (In vivo)
Synonyms
KW-3149, R14950
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19403654
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |