product name Ivabradine HCl
Description: Ivabradine HCl (also known as S 16257-2), a novel If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. Ivabradine is a new drug used for the symptomatic management of stable angina pectoris. Ivabradine acts by reducing the heart rate via specific inhibition of the funny channel, a mechanism different from that of beta blockers and calcium channel blockers, two commonly prescribed antianginal drugs.
References: Br J Pharmacol. 1994 May;112(1):37-42.
505.05
Formula
C27H36N2O5.HCl
CAS No.
148849-67-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 101 mg/mL (200 mM)
Water: 82 mg/mL (162.4 mM)
Ethanol: 101 mg/mL (200 mM)
Solubility (In vivo)
Synonyms
S 16257-2
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19398681
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
Related Posts
product name Ivabradine HCl
Description: Ivabradine HCl (also known as S 16257-2), a novel If inhibitor with IC 50 of 2.9 μM which acts specifically on the pacemaker activity of the sinoatrial node, is a pure heart rate lowering agent. Ivabradine is a new drug used for the symptomatic management of stable angina pectoris. Ivabradine acts by reducing the heart rate via specific inhibition of the funny channel, a mechanism different from that of beta blockers and calcium channel blockers, two commonly prescribed antianginal drugs.
References: Br J Pharmacol. 1994 May;112(1):37-42.
505.05
Formula
C27H36N2O5.HCl
CAS No.
148849-67-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 101 mg/mL (200 mM)
Water: 82 mg/mL (162.4 mM)
Ethanol: 101 mg/mL (200 mM)
Solubility (In vivo)
Synonyms
S 16257-2
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19398681
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |