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product name Xylometazoline HCl


Description: Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively.

References: Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.



Molecular Weight (MW)

280.84 
Formula

C16H24N2.HCl 
CAS No.

1218-35-5 
Storage

-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)

DMSO: 27 mg/mL (96.1 mM) 
Water: 56 mg/mL (199.4 mM)
Ethanol: 56 mg/mL (199.4 mM)
Solubility (In vivo)

 
Synonyms

 

other peoduct :References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19398339

In Vitro

In vitro activity: Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively.


Kinase Assay:


Cell Assay

In Vivo  
Animal model  
Formulation & Dosage  
References Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. 

Tebipenem

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Author: Sodium channel

Share this post on:

product name Xylometazoline HCl


Description: Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively.

References: Fundam Clin Pharmacol. 2010 Dec;24(6):729-39.



Molecular Weight (MW)

280.84 
Formula

C16H24N2.HCl 
CAS No.

1218-35-5 
Storage

-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)

DMSO: 27 mg/mL (96.1 mM) 
Water: 56 mg/mL (199.4 mM)
Ethanol: 56 mg/mL (199.4 mM)
Solubility (In vivo)

 
Synonyms

 

other peoduct :References PubMed ID::http://www.ncbi.nlm.nih.gov/pubmed/19398339

In Vitro

In vitro activity: Xylometazoline is an α-adrenoceptor agonist commonly used as nasal decongestant, exhibits highest potency at α2B-adrenoceptor subtype with EC50 of 99 μM. Xylometazoline binds at adrenoceptor subtypeα1A, α1B, α1D, α2A, α2B, α2C with IC50 of 0.08, 0.56, 0.45, 0.98, 1.8, 0.22μM, repectively.


Kinase Assay:


Cell Assay

In Vivo  
Animal model  
Formulation & Dosage  
References Fundam Clin Pharmacol. 2010 Dec;24(6):729-39. 

Tebipenem

Share this post on:

Author: Sodium channel