product name Sotalol HCl
Description: Sotalol HCl is a potent and non-selective antagonist of β-adrenergic receptor. It is also a potassium channel inhibitor with an IC50 value of ~1.2mM in HEK cell lines. As a class III antiarrhythmic drug, Sotalol hydrochloride has been reported to increase the functional refractory period without reducing conduction velocity, using an in vitro experimental rabbit heart model of reentrant tachycardia.
References: J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.
308.82
Formula
C12H20N2O3S.HCl
CAS No.
959-24-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 62 mg/mL (200.8 mM)
Water: 62 mg/mL (200.8 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19397817
| In Vitro |
In vitro activity: Sotalol hydrochloride is a potent and non-selective antagonist of β-adrenergic receptor. Sotalol is also an inhibitor of potassium channels with an IC50 value of ~1.2mM in HEK cell lines. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | In vivo, Sotalol hydrochloride has shown to lengthen atrial and ventricular monophasic action potential duration in the intact dog heart during constant atrial pacing. |
| Animal model | |
| Formulation & Dosage | |
| References | J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67. |
Related Posts
product name Sotalol HCl
Description: Sotalol HCl is a potent and non-selective antagonist of β-adrenergic receptor. It is also a potassium channel inhibitor with an IC50 value of ~1.2mM in HEK cell lines. As a class III antiarrhythmic drug, Sotalol hydrochloride has been reported to increase the functional refractory period without reducing conduction velocity, using an in vitro experimental rabbit heart model of reentrant tachycardia.
References: J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67.
308.82
Formula
C12H20N2O3S.HCl
CAS No.
959-24-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 62 mg/mL (200.8 mM)
Water: 62 mg/mL (200.8 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19397817
| In Vitro |
In vitro activity: Sotalol hydrochloride is a potent and non-selective antagonist of β-adrenergic receptor. Sotalol is also an inhibitor of potassium channels with an IC50 value of ~1.2mM in HEK cell lines. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | In vivo, Sotalol hydrochloride has shown to lengthen atrial and ventricular monophasic action potential duration in the intact dog heart during constant atrial pacing. |
| Animal model | |
| Formulation & Dosage | |
| References | J Pharmacol Toxicol Methods. 2006 Sep-Oct;54(2):130-40; Pacing Clin Electrophysiol. 1995 Mar;18(3 Pt 1):451-67. |