product name Salbutamol Sulfate
Description: Salbutamol Sulfate is a selective and short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. Salbutamol is used in the treatment of asthma and COPD. It is 29x fold more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.
References: Clin Sci (Lond). 1986 Feb;70(2):159-65.
337.39
Formula
C13H21NO3.H2SO4
CAS No.
51022-70-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 68 mg/mL (201.5 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Albuterol
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19397408
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Clin Sci (Lond). 1986 Feb;70(2):159-65. |
Related Posts
product name Salbutamol Sulfate
Description: Doxazosin, a quinazoline-derivative, potently and selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia. Doxazosin inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. Doxazosin nt also shows high affinity to alpha-1c adrenoceptor, the predominant functional type in the prostate, which may partially attribute to its effect in treatment of benign prostatic hyperplasia.
References: Cancer Res. 2006 Jan 1;66(1):464-72; Atherosclerosis. 1991 Nov;91(1-2):35-49.
547.58
Formula
C23H25N5O5.CH4O3S
CAS No.
77883-43-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 15 mg/mL (27.4 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19397587
| In Vitro |
In vitro activity: Doxazosin-induced apoptosis is blocked by specific caspase-8 inhibitors, supporting the functional involvement of caspase-8 in doxazosin-induced apoptosis. Doxazosin increases FADD recruitment and subsequent caspase-8 activation, implicating Fas-mediated apoptosis as the underlying mechanism of the effect of Doxazosin in prostate cells. Doxazosin and cholestyramine similarly decreases plasma total and LDL plus VLDL cholesterols, and total triglycerides on average by 46%, 61% and 45% respectively. Doxazosin induces DNA damage and cell death in HL-1 cell line. Doxazosin treatment decreases cell viability in primary cultures of neonatal rat cardiomyocytes, and Hoechst dye vital staining demonstrates doxazosin-induced apoptosis in primary cultures of human adult cardiomyocytes. Doxazosin antagonizes the VEGF-mediated angiogenic response of HUVEC cells, by abrogating cell adhesion to fibronectin and collagen-coated surfaces and inhibiting cell migration, via a potential downregulation of VEGF expression. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Doxazosin also reduces mean arterial pressure by 18% without affecting heart rate in all hamsters. Doxazosin causes a significant reduction in the wet weight of BabeTGF-beta 1-infected mouse prostate reconstitution (MPR). |
| Animal model | |
| Formulation & Dosage | |
| References | Cancer Res. 2006 Jan 1;66(1):464-72; Atherosclerosis. 1991 Nov;91(1-2):35-49; Prostate. 1997 Nov 1;33(3):157-63. |
Related Posts
product name Salbutamol Sulfate
Description: Salbutamol Sulfate is a selective and short-acting β2-adrenergic receptor agonist with an IC50 of 8.93 µM. Salbutamol is used in the treatment of asthma and COPD. It is 29x fold more selective for beta2 receptors than beta1 receptors giving it higher specificity for pulmonary beta receptors versus beta1-adrenergic receptors located in the heart.
References: Clin Sci (Lond). 1986 Feb;70(2):159-65.
337.39
Formula
C13H21NO3.H2SO4
CAS No.
51022-70-9
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 68 mg/mL (201.5 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
Albuterol
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19397408
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Clin Sci (Lond). 1986 Feb;70(2):159-65. |
Related Posts
product name Salbutamol Sulfate
Description: Doxazosin, a quinazoline-derivative, potently and selectively antagonizes postsynaptic α1-adrenergic receptors, used in the treatment of high blood pressure and urinary retention associated with benign prostatic hyperplasia. Doxazosin inhibits the binding of norepinephrine, which is released from sympathetic nerve terminals, to the α-1 receptors on the membrane of vascular smooth muscle cells. Doxazosin nt also shows high affinity to alpha-1c adrenoceptor, the predominant functional type in the prostate, which may partially attribute to its effect in treatment of benign prostatic hyperplasia.
References: Cancer Res. 2006 Jan 1;66(1):464-72; Atherosclerosis. 1991 Nov;91(1-2):35-49.
547.58
Formula
C23H25N5O5.CH4O3S
CAS No.
77883-43-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 15 mg/mL (27.4 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19397587
| In Vitro |
In vitro activity: Doxazosin-induced apoptosis is blocked by specific caspase-8 inhibitors, supporting the functional involvement of caspase-8 in doxazosin-induced apoptosis. Doxazosin increases FADD recruitment and subsequent caspase-8 activation, implicating Fas-mediated apoptosis as the underlying mechanism of the effect of Doxazosin in prostate cells. Doxazosin and cholestyramine similarly decreases plasma total and LDL plus VLDL cholesterols, and total triglycerides on average by 46%, 61% and 45% respectively. Doxazosin induces DNA damage and cell death in HL-1 cell line. Doxazosin treatment decreases cell viability in primary cultures of neonatal rat cardiomyocytes, and Hoechst dye vital staining demonstrates doxazosin-induced apoptosis in primary cultures of human adult cardiomyocytes. Doxazosin antagonizes the VEGF-mediated angiogenic response of HUVEC cells, by abrogating cell adhesion to fibronectin and collagen-coated surfaces and inhibiting cell migration, via a potential downregulation of VEGF expression. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Doxazosin also reduces mean arterial pressure by 18% without affecting heart rate in all hamsters. Doxazosin causes a significant reduction in the wet weight of BabeTGF-beta 1-infected mouse prostate reconstitution (MPR). |
| Animal model | |
| Formulation & Dosage | |
| References | Cancer Res. 2006 Jan 1;66(1):464-72; Atherosclerosis. 1991 Nov;91(1-2):35-49; Prostate. 1997 Nov 1;33(3):157-63. |