product name Schisandrin B
Description: Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. In vitro: Schisandrin B has early been found to inhibit in vitro lipid peroxidation by NADPH/ ascorbate and cysteine/ferric systems in isolated rat liver microsomes. In addition, using electron spin resonance measurement, Sch B was shown to scavenge both in vitro hydroxyl and superoxide radicals. In contrast to that α-tocopherol produced prooxidant and antioxidant effect on Fe3+-induced lipid peroxidation, Sch B could only inhibit the peroxidation reaction.
References: Mol Cell Biochem. 1996 Dec 20;165(2):161-5; PLoS One. 2015 Mar 5;10(3):e0119214.
400.46
Formula
C23H28O6
CAS No.
61281-37-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 80 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 10 mg/mL (25.0 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19395411
| In Vitro |
In vitro activity: Schisandrin B is able to induce high level of apoptosis in human hepatic carcinoma cells and human leukemia cells. Schisandrin B decreases the viability of adenocarcinoma cells after UV exposure. The specific inhibitory effect of schisandrin B on ATR protein kinase activity (a DNA repair enzyme) following DNA damage in cells may be useful in anti-cancer therapy. Schisandrin B is found to be the only molecule being a cardioprotective agent as well as a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1, which is potentially applicable to treat cancers, especially those displaying multidrug resistance Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Schisandrin B can protect liver against toxicant challenge. Schisandrin B pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice. Further studies demonstrate the protective effect of schisandrin B on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin. Moreover, schisandrin B is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion. |
| Animal model | |
| Formulation & Dosage | |
| References | Free Radic Biol Med. 1996;21(5):709-12; Cell Stress Chaperones. 2001 Jan;6(1):44-8. |
Related Posts
product name Schisandrin B
Description: Schisandrin B is the most abundant dibenzocyclooctadiene lignan present in the traditional Chinese medicinal herb Schisandra chinensis (Turcz.) Baill. In vitro: Schisandrin B has early been found to inhibit in vitro lipid peroxidation by NADPH/ ascorbate and cysteine/ferric systems in isolated rat liver microsomes. In addition, using electron spin resonance measurement, Sch B was shown to scavenge both in vitro hydroxyl and superoxide radicals. In contrast to that α-tocopherol produced prooxidant and antioxidant effect on Fe3+-induced lipid peroxidation, Sch B could only inhibit the peroxidation reaction.
References: Mol Cell Biochem. 1996 Dec 20;165(2):161-5; PLoS One. 2015 Mar 5;10(3):e0119214.
400.46
Formula
C23H28O6
CAS No.
61281-37-6
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 80 mg/mL (199.8 mM)
Water: <1 mg/mL
Ethanol: 10 mg/mL (25.0 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19395411
| In Vitro |
In vitro activity: Schisandrin B is able to induce high level of apoptosis in human hepatic carcinoma cells and human leukemia cells. Schisandrin B decreases the viability of adenocarcinoma cells after UV exposure. The specific inhibitory effect of schisandrin B on ATR protein kinase activity (a DNA repair enzyme) following DNA damage in cells may be useful in anti-cancer therapy. Schisandrin B is found to be the only molecule being a cardioprotective agent as well as a dual inhibitor of P-glycoprotein and multidrug resistance-associated protein 1, which is potentially applicable to treat cancers, especially those displaying multidrug resistance Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Schisandrin B can protect liver against toxicant challenge. Schisandrin B pretreatment protects against carbon tetrachloride- or TNFα-induced liver damage in mice. Further studies demonstrate the protective effect of schisandrin B on free radical-induced damage in various vital organs, including the heart, liver, kidney, brain and skin. Moreover, schisandrin B is found to attenuate cancer invasion and metastasis via inhibiting epithelial mesenchymal transition at the step of local invasion. |
| Animal model | |
| Formulation & Dosage | |
| References | Free Radic Biol Med. 1996;21(5):709-12; Cell Stress Chaperones. 2001 Jan;6(1):44-8. |