product name Formestane
Description: Formestane (also known as CGP-32349, NSC 282175) is a second generation, selective, orally active, synthetic steroidal aromatase inhibitor with an IC50 of 80 nM. Formestane is a substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
References: Steroids. 2013 Nov;78(11):1103-9; Ann Oncol. 1994;5 Suppl 7:S19-24.
302.41
Formula
C19H26O3
CAS No.
566-48-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 61 mg/mL (201.7 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
CGP-32349, NSC 282175
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19393346
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
Related Posts
product name Formestane
Description: Formestane (also known as CGP-32349, NSC 282175) is a second generation, selective, orally active, synthetic steroidal aromatase inhibitor with an IC50 of 80 nM. Formestane is a substance with antineoplastic activity. Formestane binds irreversibly to and inhibits the enzyme aromatase, thereby blocking the conversion of cholesterol to pregnenolone and the peripheral aromatization of androgenic precursors into estrogens.
References: Steroids. 2013 Nov;78(11):1103-9; Ann Oncol. 1994;5 Suppl 7:S19-24.
302.41
Formula
C19H26O3
CAS No.
566-48-3
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 61 mg/mL (201.7 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
CGP-32349, NSC 282175
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19393346
| In Vitro |
In vitro activity: Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |