product name Hyoscyamine
Description: Hyoscyamine is a highly potent AChR inhibitor with IC50 of 7.5 nM. L-hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells.
References: Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8.
289.37
Formula
C17H23NO3
CAS No.
101-31-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 58 mg/mL (200.4 mM)
Water: <1 mg/mL
Ethanol: 58 mg/mL (200.4 mM)
Solubility (In vivo)
30% Propylene glycol, 5% Tween 80, 65% D5W: 5 mg/mL
Synonyms
Daturine
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19392833
| In Vitro |
In vitro activity: -hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively. Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells. S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | L-hyoscyamine (20 mg/kg) prolongs migrating myoelectric complex (MMC) cycle length from 17.6 min to 29.0 min in conscious rats. |
| Animal model | Rat |
| Formulation & Dosage | Dissolved in saline; 20 mg/kg; i.v. injection |
| References | Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8. |
Related Posts
product name Hyoscyamine
Description: Hyoscyamine is a highly potent AChR inhibitor with IC50 of 7.5 nM. L-hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells.
References: Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8.
289.37
Formula
C17H23NO3
CAS No.
101-31-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 58 mg/mL (200.4 mM)
Water: <1 mg/mL
Ethanol: 58 mg/mL (200.4 mM)
Solubility (In vivo)
30% Propylene glycol, 5% Tween 80, 65% D5W: 5 mg/mL
Synonyms
Daturine
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19392833
| In Vitro |
In vitro activity: -hyoscyamine increases the turnover number of GTPase activity from 0.19 min-1 to 2.11 min-1 in the steady-state kinetic measurements. R-(+)-hyoscyamine results in displacement of [3H]NMS binding to the muscarinic acetylcholine receptor subtypes (m1-m5) with pKi value of 8.67, 8.51, 7.46, 8.56 and 8.53, respectively. Hyoscyamine prevents the agonist-induced stimulation of cAMP production with EC50 of 7.8 nM in CHO cells. S-(-)-hyoscyamine enhances the forskolin-stimulated synthesis of cyclic AMP in rat cardiac (both atrial and ventricular) membranes by up to 24%. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | L-hyoscyamine (20 mg/kg) prolongs migrating myoelectric complex (MMC) cycle length from 17.6 min to 29.0 min in conscious rats. |
| Animal model | Rat |
| Formulation & Dosage | Dissolved in saline; 20 mg/kg; i.v. injection |
| References | Biochemistry. 1987 Dec 15;26(25):8175-82; Eur J Pharmacol. 2003 Apr 25;467(1-3):211-8. |