product name Diphemanil Methylsulfate
Description: Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR). Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth muscle spasmolytic activity.
References: Eur J Clin Pharmacol. 1992;42(6):689-91.
389.51
Formula
C20H24N.CH3O4S
CAS No.
62-97-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 25 mg/mL (64.2 mM)
Water: 28 mg/mL (71.9 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19392693
| In Vitro |
In vitro activity: Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth muscle spasmolytic activity. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%. |
| Animal model | |
| Formulation & Dosage | |
| References | Eur J Clin Pharmacol. 1992;42(6):689-91. |
Related Posts
product name Diphemanil Methylsulfate
Description: Diphemanil Methylsulfate is a quaternary ammonium anticholinergic, it binds muscarinic acetycholine receptors (mAchR). Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth muscle spasmolytic activity.
References: Eur J Clin Pharmacol. 1992;42(6):689-91.
389.51
Formula
C20H24N.CH3O4S
CAS No.
62-97-5
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 25 mg/mL (64.2 mM)
Water: 28 mg/mL (71.9 mM)
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19392693
| In Vitro |
In vitro activity: Diphemanil Methylsulfate exerts its action by primarily binding the muscarinic M3 receptor. In addition to its well known antimuscarinic effects, Diphemanil Methylsulfate also possesses direct smooth muscle spasmolytic activity. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | The pharmacokinetic experiments show that absorption of diphemanil methylsulphate is slow (tmax = 2 to 4 h), the mean half-life is 8.35 h, and the amount of the drug recovered in urine within 48 h ranges from 0.6 to 7.4% of the administered dose. Poorly absorbed from the gastrointestinal tract with an absolute bioavailability of 15 to 25%. |
| Animal model | |
| Formulation & Dosage | |
| References | Eur J Clin Pharmacol. 1992;42(6):689-91. |