product name Otilonium Bromide
Description: Otilonium bromide is an antimuscarinic used to relieve spasmodic pain of the gut especially irritable bowel syndrome. Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect.
References: Arch Int Pharmacodyn Ther. 1983 Aug;264(2):305-23; Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10.
563.57
Formula
C29H43BrN2O4
CAS No.
26095-59-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 113 mg/mL (200.5 mM)
Water: 113 mg/mL (200.5 mM)
Ethanol: 113 mg/mL (200.5 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19392610
| In Vitro |
In vitro activity: Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Arch Int Pharmacodyn Ther. 1983 Aug;264(2):305-23; Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10. |
Related Posts
product name Otilonium Bromide
Description: Otilonium bromide is an antimuscarinic used to relieve spasmodic pain of the gut especially irritable bowel syndrome. Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect.
References: Arch Int Pharmacodyn Ther. 1983 Aug;264(2):305-23; Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10.
563.57
Formula
C29H43BrN2O4
CAS No.
26095-59-0
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 113 mg/mL (200.5 mM)
Water: 113 mg/mL (200.5 mM)
Ethanol: 113 mg/mL (200.5 mM)
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19392610
| In Vitro |
In vitro activity: Otilonium bromide is a quaternary ammonium compound whose spasmolytic action, selective on the distal gastrointestinal tract, is mainly due to its direct myolytic properties. This drug modifies Ca2+ fluxes from extracellular and intracellular pools in the intestinal smooth muscle and is poorly absorbed, thus it exerts its action locally, without any considerable systemic effect. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References | Arch Int Pharmacodyn Ther. 1983 Aug;264(2):305-23; Aliment Pharmacol Ther. 1998 Oct;12(10):1003-10. |