product name Amfebutamone (Bupropion) HCl
Description: Amfebutamone HCl (also known as Bupropion) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively. Amfebutamone HCl is a medication primarily used as an antidepressant and smoking cessation aid. It is one of the most frequently prescribed antidepressants in the United States.
References: J Pharmacol Exp Ther. 1999 Jan;288(1):88-92.
276.2
Formula
C13H18ClNO.HCl
CAS No.
31677-93-7
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 8 mg/mL (28.96 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19391040
| In Vitro |
In vitro activity: Bupropion hydrochloride is an aminoketone used as non-nicotine aid to smoking cessation. Bupropion hydrochloride is also a typical antidepressant agent that interferes with norepinephrine, serotonin, and dopamine reuptake. In addition, Bupropion hydrochloride has been reported to reduce the expression of tyrosine hydroxylase, a rate-limiting enzyme in dopamine biosynthesis. In vitro, it has been shown that Bupropion hydrochloride can decrease cell viability significantly in SH-SY5Y cells. Furthermore, Bupropion hydrochloride has been revealed to selectively activate an ER stress pathway. Apart from these, the result has also shown that Bupropion hydrochloride can induce cell death as a result of caspase 3 activation through the JNK and ER stress. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |
Related Posts
product name Amfebutamone (Bupropion) HCl
Description: Amfebutamone HCl (also known as Bupropion) is a selective norepinephrine-dopamine reuptake inhibitor with IC50 of 6.5 and 3.4 μM for the reuptake of dopamine and norepinephrine, respectively. Amfebutamone HCl is a medication primarily used as an antidepressant and smoking cessation aid. It is one of the most frequently prescribed antidepressants in the United States.
References: J Pharmacol Exp Ther. 1999 Jan;288(1):88-92.
276.2
Formula
C13H18ClNO.HCl
CAS No.
31677-93-7
Storage
-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)
DMSO: 8 mg/mL (28.96 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
Solubility (In vivo)
Synonyms
other peoduct :References PubMed ID：:http://www.ncbi.nlm.nih.gov/pubmed/19391040
| In Vitro |
In vitro activity: Bupropion hydrochloride is an aminoketone used as non-nicotine aid to smoking cessation. Bupropion hydrochloride is also a typical antidepressant agent that interferes with norepinephrine, serotonin, and dopamine reuptake. In addition, Bupropion hydrochloride has been reported to reduce the expression of tyrosine hydroxylase, a rate-limiting enzyme in dopamine biosynthesis. In vitro, it has been shown that Bupropion hydrochloride can decrease cell viability significantly in SH-SY5Y cells. Furthermore, Bupropion hydrochloride has been revealed to selectively activate an ER stress pathway. Apart from these, the result has also shown that Bupropion hydrochloride can induce cell death as a result of caspase 3 activation through the JNK and ER stress. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | |
| Animal model | |
| Formulation & Dosage | |
| References |