Product Name :
MM-589 TFA
Description:
MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.
CAS:
2097887-21-1
Molecular Weight:
686.72
Formula:
C30H45F3N8O7
Chemical Name:
N-[(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N”-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl]-2-methylpropanamide; trifluoroacetic acid
Smiles :
C[C@]1(CCNC(=O)[C@H](NC(=O)[C@H](CC)NC(=O)[C@H](CCCNC(N)=NC)NC1=O)C1C=CC=CC=1)NC(=O)C(C)C.OC(=O)C(F)(F)F
InChiKey:
NARXNZHWAWPJIY-HTCBAMNXSA-N
InChi :
InChI=1S/C28H44N8O5.C2HF3O2/c1-6-19-23(38)35-21(18-11-8-7-9-12-18)25(40)31-16-14-28(4,36-22(37)17(2)3)26(41)34-20(24(39)33-19)13-10-15-32-27(29)30-5;3-2(4,5)1(6)7/h7-9,11-12,17,19-21H,6,10,13-16H2,1-5H3,(H,31,40)(H,33,39)(H,34,41)(H,35,38)(H,36,37)(H3,29,30,32);(H,6,7)/t19-,20-,21+,28+;/m0.{{Valbenazine} medchemexpress|{Valbenazine} Membrane Transporter/Ion Channel|{Valbenazine} Purity & Documentation|{Valbenazine} In Vivo|{Valbenazine} manufacturer|{Valbenazine} Cancer} /s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM.|Product information|CAS Number: 2097887-21-1|Molecular Weight: 686.72|Formula: C30H45F3N8O7|Chemical Name: N-[(3R,6S,9S,12R)-6-ethyl-12-methyl-9-[3-(N”-methylcarbamimidamido)propyl]-2,5,8,11-tetraoxo-3-phenyl-1,4,7,10-tetraazacyclotetradecan-12-yl]-2-methylpropanamide; trifluoroacetic acid|Smiles: C[C@]1(CCNC(=O)[C@H](NC(=O)[C@H](CC)NC(=O)[C@H](CCCNC(N)=NC)NC1=O)C1C=CC=CC=1)NC(=O)C(C)C.{{Anti-Mouse LAG-3 Antibody} medchemexpress|{Anti-Mouse LAG-3 Antibody} Immunology/Inflammation|{Anti-Mouse LAG-3 Antibody} Protocol|{Anti-Mouse LAG-3 Antibody} Purity|{Anti-Mouse LAG-3 Antibody} manufacturer|{Anti-Mouse LAG-3 Antibody} Epigenetics} OC(=O)C(F)(F)F|InChiKey: NARXNZHWAWPJIY-HTCBAMNXSA-N|InChi: InChI=1S/C28H44N8O5.PMID:23551549 C2HF3O2/c1-6-19-23(38)35-21(18-11-8-7-9-12-18)25(40)31-16-14-28(4,36-22(37)17(2)3)26(41)34-20(24(39)33-19)13-10-15-32-27(29)30-5;3-2(4,5)1(6)7/h7-9,11-12,17,19-21H,6,10,13-16H2,1-5H3,(H,31,40)(H,33,39)(H,34,41)(H,35,38)(H,36,37)(H3,29,30,32);(H,6,7)/t19-,20-,21+,28+;/m0./s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.|Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations.|Products are for research use only. Not for human use.|
