Product Name :
T-2513
Description:
T-2513 is a selective topoisomerase I inhibitor. T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death.
CAS:
288247-87-0
Molecular Weight:
449.50
Formula:
C25H27N3O5
Chemical Name:
(19S)-7-(3-aminopropoxy)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Smiles :
CC[C@]1(O)C2C=C3C4=NC5=CC=C(C=C5C(CC)=C4CN3C(=O)C=2COC1=O)OCCCN
InChiKey:
XZLHHOGJQUVONU-VWLOTQADSA-N
InChi :
InChI=1S/C25H27N3O5/c1-3-15-16-10-14(32-9-5-8-26)6-7-20(16)27-22-17(15)12-28-21(22)11-19-18(23(28)29)13-33-24(30)25(19,31)4-2/h6-7,10-11,31H,3-5,8-9,12-13,26H2,1-2H3/t25-/m0/s1
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.{{Emixustat} site|{Emixustat} Protocol|{Emixustat} Description|{Emixustat} manufacturer|{Emixustat} Cancer}
Additional information:
T-2513 is a selective topoisomerase I inhibitor.{{Domvanalimab} medchemexpress|{Domvanalimab} Biological Activity|{Domvanalimab} Description|{Domvanalimab} manufacturer|{Domvanalimab} Epigenetic Reader Domain} T-2513 binds covalently to and stabilizes the topoisomerase I-DNA complex and inhibits DNA replication and RNA synthesis, ultimately leading to cell death.|Product information|CAS Number: 288247-87-0|Molecular Weight: 449.50|Formula: C25H27N3O5|Chemical Name: (19S)-7-(3-aminopropoxy)-10,19-diethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.0²,¹¹.0⁴,⁹.0¹⁵,²⁰]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione|Smiles: CC[C@]1(O)C2C=C3C4=NC5=CC=C(C=C5C(CC)=C4CN3C(=O)C=2COC1=O)OCCCN|InChiKey: XZLHHOGJQUVONU-VWLOTQADSA-N|InChi: InChI=1S/C25H27N3O5/c1-3-15-16-10-14(32-9-5-8-26)6-7-20(16)27-22-17(15)12-28-21(22)11-19-18(23(28)29)13-33-24(30)25(19,31)4-2/h6-7,10-11,31H,3-5,8-9,12-13,26H2,1-2H3/t25-/m0/s1|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.PMID:26760947 |Shelf Life: ≥12 months if stored properly.|Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|SN-38 is the metabolite of T-2513. T-2513 has a broad cytotoxicity against a range of human tumor cell lines.|In Vivo:|T-2513 (1-100 mg/kg) shows Antitumor Activity against Walker-256 carcinoma.|Products are for research use only. Not for human use.|
