Product Name :
AP-C5
Description:
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.2, which can be used for the research of diarrheal disease.
CAS:
2234272-10-5
Molecular Weight:
275.31
Formula:
C16H13N5
Chemical Name:
4-[4-(1H-imidazol-1-yl)phenyl]-N-(prop-2-yn-1-yl)pyrimidin-2-amine
Smiles :
C#CCNC1=NC(=CC=N1)C1C=CC(=CC=1)N1C=NC=C1
InChiKey:
QKHQFSQJQKGFAA-UHFFFAOYSA-N
InChi :
InChI=1S/C16H13N5/c1-2-8-18-16-19-9-7-15(20-16)13-3-5-14(6-4-13)21-11-10-17-12-21/h1,3-7,9-12H,8H2,(H,18,19,20)
Purity:
≥98% (or refer to the Certificate of Analysis)
Shipping Condition:
Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis
Storage Condition :
Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.
Shelf Life:
≥12 months if stored properly.
Stock Solution Storage:
0 – 4 oC for 1 month or refer to the Certificate of Analysis.
Additional information:
AP-C5 displays selective inhibition of guanosine 3′,5′-cyclic monophosphate (cGMP)-dependent protein kinase II (cGKII) with a pIC50 of 7.{{Mizoribine} MedChemExpress|{Mizoribine} SARS-CoV|{Mizoribine} Technical Information|{Mizoribine} In Vivo|{Mizoribine} custom synthesis|{Mizoribine} Cancer} 2, which can be used for the research of diarrheal disease.|Product information|CAS Number: 2234272-10-5|Molecular Weight: 275.31|Formula: C16H13N5|Chemical Name: 4-[4-(1H-imidazol-1-yl)phenyl]-N-(prop-2-yn-1-yl)pyrimidin-2-amine|Smiles: C#CCNC1=NC(=CC=N1)C1C=CC(=CC=1)N1C=NC=C1|InChiKey: QKHQFSQJQKGFAA-UHFFFAOYSA-N|InChi: InChI=1S/C16H13N5/c1-2-8-18-16-19-9-7-15(20-16)13-3-5-14(6-4-13)21-11-10-17-12-21/h1,3-7,9-12H,8H2,(H,18,19,20)|Technical Data|Appearance: Solid Power|Purity: ≥98% (or refer to the Certificate of Analysis)|Shipping Condition: Shipped under ambient temperature as non-hazardous chemical or refer to Certificate of Analysis|Storage Condition: Dry, dark and -20 oC for 1 year or refer to the Certificate of Analysis.{{Amcenestrant} medchemexpress|{Amcenestrant} Vitamin D Related/Nuclear Receptor|{Amcenestrant} Biological Activity|{Amcenestrant} Purity|{Amcenestrant} supplier|{Amcenestrant} Epigenetics} |Shelf Life: ≥12 months if stored properly.PMID:35901518 |Stock Solution Storage: 0 – 4 oC for 1 month or refer to the Certificate of Analysis.|Drug Formulation: To be determined|HS Tariff Code: 382200|How to use|In Vitro:|AP-C5 shows potent inhibition of cGMP-dependent cGKII-mediated protein phosphorylation and effective inhibition of cGMP-dependent, CFTR-mediated anion secretion in intestinal tissue. AP-C5 potentiates cAMP signaling by PDE inhibition. AP-C5 (20 μM) partially blocks the heat-stable toxin (STa)-mediated short-circuit current (Isc) response in mouse ileum.|Products are for research use only. Not for human use.|
