De Barcelona, Barcelona, Spain. ten Departament de Medicina, Universitat Aut oma deDe Barcelona, Barcelona, Spain.

De Barcelona, Barcelona, Spain. ten Departament de Medicina, Universitat Aut oma de
De Barcelona, Barcelona, Spain. ten Departament de Medicina, Universitat Aut oma de Barcelona, Barcelona, Spain. 11Servei de Pneumologia, Hospital de Bellvitge, Feixa Llarga s/n, 08907L Hospitalet de Llobregat, Spain. 12IDIBELL (Institut d’InvestigaciBiom ica de Bellvitge), Gran Via de L’Hospitalet 199, 08908 Hospitalet de Llobregat, Spain. 13Arizona Respiratory Center, Tucson, AZ, USA. 14Servei de Pneumologia, Hospital Universitari Son Espases, Carretera de Valldemosa 79, 07010 Palma de Mallorca, Spain. 15Institut de InvestigaciSanit ia de Palma (IdISPa), Carretera de Valldemossa 79, Palma, Spain. 16Thorax Institute, Hospital Cl ic, Barcelona, Spain. 17Institut d’InvestigaciBiom ica AgustPi I Sunyer (IDIBAPS), Barcelona, Spain. 18Universitat de Barcelona, Barcelona, Spain. 19FundaciInvestigaciSanit ia Illes Balears (FISIB), Palma de Mallorca, Spain. Received: 4 January 2015 Accepted: eight January 2015 Published: 17 January 2015 References 1. Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, et al. Chronic obstructive H2 Receptor Biological Activity pulmonary illness: existing burden and future projections. Eur Respir J. 2006;27:39712. two. Murray CJ, L ez AD. Measuring the Global Burden of Illness. N Engl J Med. 2013;369:4487. three. Coultas DB, Mapel D, Gagnon R, Lydick E. The wellness effect of undiagnosed airflow obstruction inside a national sample of United states adults. Am J Respir Crit Care Med. 2001;164:372. four. Rennard S, Decramer M, Calverley PM, Pride NB, Soriano JB, Vermeire PA, et al. Effect of COPD in North America and Europe in 2000: subjects’ viewpoint of Confronting COPD International Survey. Eur Respir J. 2002;20:79905. five. Soriano JB, Ancochea J, Miravitlles M, Garc -R F, Duran-Tauleria E, Mu z L, et al. Current trends in COPD prevalence in Spain: a repeated cross-sectional survey 1997007. Eur Respir J. 2010;36:7585. 6. Soriano JB, Miravitlles M, Border s L, Duran-Tauleria E, Garc R F, Mart ez J, et al. Geographical variations inside the prevalence of COPD in Spain: Partnership to Smoking, Death Prices along with other Figuring out Components. Arch Bronconeumol. 2010;46:5220. 7. Bednarek M, Maciejewski J, Wozniak M, Kuca P, Zielinski J. Prevalence, severity and underdiagnosis of COPD in the main care setting. Thorax. 2008;63:402. eight. Jordan RE, Lam KB, Cheng KK, Miller MR, Marsh JL, Ayres JG, et al. Case finding for chronic obstructive pulmonary disease: a model for optimising a targered method. Thorax. 2010;65:492. 9. Miravitlles M, Soriano JB, Garc -R F, Mu z L, Duran-Tauleria E, Sanchez G, et al. Prevalence of COPD in Spain: IKK-β MedChemExpress influence of undiagnosed COPD on excellent of life and day-to-day life activities. Thorax. 2009;64:863. ten. Soriano JB, Zielinski J, Price D. Screening for and early detection of chronic obstructive pulmonary disease. Lancet. 2009;374:7212. 11. Zoia MC, Corsico AG, Beccaria M, Guarnone R, Cervio G, Testi R, et al. Exacerbations as a starting point of pro-active chronic obstructive pulmonary illness management. Respir Med. 2005;99:15685. 12. Bastin AJ, Starling L, Ahmed R, Dinham A, Hill N, Stern M, et al. Higher prevalence of undiagnosed and serious chronic obstructive pulmonary disease initially hospital admission with acute exacerbation. Chron Respir Dis. 2010;7:91. 13. Garcia-Aymerich J, G ez FP, AntJM. Phenotypic characterization and course of chronic obstructive pulmonary illness (COPD) inside the PAC-COPD Study: design and style and approaches. Arch Bronconeumol. 2009;45:41. 14. BarberJA, Peces-Barba G, AgustAG, Izquierdo JL, MonsE, Montemayor T, et al. Clinical.