Reare situated at phenyl C2 (opposite dole (1a), the by far the mostReare situated at

Reare situated at phenyl C2 (opposite dole (1a), the by far the most
Reare situated at phenyl C2 (opposite dole (1a), the probably the most positively charged hydrogens located at phenyl C2 (opposite to to the pyridine nitrogen in bold) and azaindole C2 (next thethe pyrrole nitrogen) whilst the pyridine nitrogen in bold) and azaindole C2 (subsequent to to pyrrole nitrogen) while the the most stabilized lithiated derivative can also be at C2 (FigureIt is interesting to know know most stabilized lithiated derivative is also at C2 (Figure 4B). 4B). It is interesting to which which of the lithiated intermediates is intercepted by Zn(TMP)2 during such a LiTMPmediated deprotonation.Molecules 2021, 26, x FOR PEER REVIEW8 ofMolecules 2021, 26,on the lithiated intermediates is intercepted by Zn(TMP)two throughout such a LiTMP-mediated 8 of 33 deprotonation. Molecules 2021, 26, x FOR PEER Assessment 88of 34 of 34 Molecules 2021, 26, x FOR PEER Evaluation For this 8 of 34 of 34 Molecules 2021, 26, x FOR PEER Evaluation 26, x FOR PEER x FOR PEER Assessment 8 of 34 Molecules 2021, 26,Review Molecules 2021, 26, x FOR PEER Combretastatin A-1 Epigenetic Reader Domain Critique eight of 34 Molecules 2021, Molecules 2021, 26, x FOR PEER REVIEWpurpose, 1a was treated at rt for 2 h by the fundamental mixture 8prepared in 8 of 34 situ in THF from RP101988 web ZnCl2TMEDA (1 equiv) and LiTMP (three equiv), and iodine was added to For this objective, 1a was treated at Beneath these conditions, the 2-iodinated derivaquench the organometallic intermediate.rt for 2 h by the basic combination prepared in in the ZnCl TMEDA (1 by in the THF ofthe lithiated intermediates is intercepted byduring suchduringsuch aaLiTMP-mediated situ the lithiated thelithiated2intermediates isequiv) andbyduring suchThis can outcome either from direct in lithiated intermediates is interceptedintercepted byZn(TMP)22 2during such a LiTMP-mediated in the lithiated intermediates a yield of 75 Zn(TMP)two,for the duration of such a LiTMP-mediated was added to intermediates is intercepted intercepted two entry 1). a LiTMP-mediated ofisolated with is intercepted by Zn(TMP)two Zn(TMP) throughout and LiTMP-mediated of tive 3a was fromlithiated ntermediates is by Zn(TMP)2LiTMP (32 equiv),such iodine (Table Zn(TMP) a LiTMP-mediated deprotonation. deprotonation. deprotonation. deprotonation. deprotonation. quench thedeprotonation. orintermediate. Under these situations, the 2-iodinated derivative organometallic from deprotonation at a different position (directed by the pyrideprotolithiation this C2 treatedwasrt treatedatbyrtthe basicbythe standard combinationin preparedin For at For this objective, 1a was treated wastreatedh by the 22hhby the fundamental combinationprepared in mixture ready prepared in For this for For this objective, goal, 1a at rt for 2 h by for standard mixture prepared in 2 For this objective, 1a at treated at rt for two by For this purpose, 1a purpose,1a 75 for 2 h atrt the basic1).the fundamental combinationin 3a was THFsitu inZnCl21aawasby (1of wasrtand equiv)beforehtransmetalation to aeitherspecies. This isolated with was treated at for LiTMP (3 equiv), combination prepared to yield entry This can result from dine in THFsitu inZnCl22from ZnClisomerization, 2,(three equiv), andequiv), and iodine was added to direct nitrogen) followedZnCl22TMEDA (Table and LiTMPand iodine was added to added to situ in THF frominTHF TMEDA (1TMEDA (1 equiv) andequiv), andequiv), and iodine was added to from ZnCl from ZnCl2equiv) and LiTMP (3 LiTMP (three iodine was added to situ THFTMEDA two TMEDA(1 equiv) from (three equiv), and iodine was situ from THF TMEDA (1 equiv) and LiTMP and LiTMP(3 iodine was added zinc equiv) (1 situ.